The best way to predict future is to invent it.
- Alan Kay
Syntab Therapeutics has demonstrated the ISEr concept in 2 different publications in high ranking journals by now, one more is currently in preparation.
Brehs M et al. (2017) Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation. Scientific Reports 7, 17592. DOI: 10.1038/s41598-017-17627-0
Conibear AC et al. (2018) Synthetic cancer-targeting innate immune stimulators give insights into avidity effects. ChemBioChem 19, 459-469 DOI:10.1002/cbic.201700522
Pötgens AJG et al. (2019) Tumor-Targeting Immune System Engagers (ISErs) Activate Human Neutrophils after Binding to Cancer Cells. Biochemistry 58, 2642-2652. DOI: 10.1021/acs.biochem.9b00169