Modular approach offers multiple options
The ISErs combine highly selective binders for recognizing cancer cells and immune activators in one small molecule of 5 to 10 kD. Such molecules are extraordinarily flexible in design and simple in chemical production and can be designed to the needs to fight against a specific cancer. An ISEr can have up to four different binder arms targeting multiple cancer cell specific markers besides the immune activator. Being such flexible molecules, the ISErs can be produced chemically within only a few days with low costs.